HTLV-1 viro-immunology elucidated using thinkpeptides
Rowan et al. Retrovirology 2014 11:116 Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression
Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that has been implicated in several types of human disease including aggressive T cell lymphoma. In this study Rowan et al used HTLV-1 specific CTL clones that had been expanded using peptides from thinkpeptides to gain a better understanding of the relevance of HTLV-1 HBZ and TAX proteins in immune responses to HTLV-1 infection. Both proteins are important in the virus life cycle, but TAX is clearly much more immunogenic. This suggests that HTLV-1 is under pressure to optimize the use of these proteins in its life cycle to thrive.
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