Epitope map of Israeli Acute Paralysis Virus could help save declining honey bees

Ren J. et al., Assembly of Recombinant Israeli Acute Paralysis Virus Capsids doi:10.1371/journal.pone.0105943.g003


Israeli Acute Paralysis Virus (IAPV) has been implicated in the worldwide decline of honey  bees. Ren et al studied the molecular protein biochemistry of how IAPV expresses and assembles into virus particles in insect cells. Monoclonal antibodies developed by Ren et al. specific to IAPV capsid proteins and an understanding of the highly specific epitopes they recognize as determined by Ren et al. could contribute to diagnostic tests to detect this bee pathogen. Such tests could play an important role in developing a better understanding of the epidemiology of IAPV in the honey bee population.

Peptides for epitope mapping for this study were custom synthesized by thinkpeptides.

Fig 5A. Linear antibody epitope map of 4 monoclonal antibodies to IAPV VP2 on an overlapping peptide library. doi:10.1371/journal.pone.0105943.g005

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